DICER1 hot-spot mutations in ovarian gynandroblastoma
نویسندگان
چکیده
منابع مشابه
Recurrent somatic DICER1 mutations in nonepithelial ovarian cancers.
BACKGROUND Germline truncating mutations in DICER1, an endoribonuclease in the RNase III family that is essential for processing microRNAs, have been observed in families with the pleuropulmonary blastoma-family tumor and dysplasia syndrome. Mutation carriers are at risk for nonepithelial ovarian tumors, notably sex cord-stromal tumors. METHODS We sequenced the whole transcriptomes or exomes ...
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Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Laboratory of Sequence Data Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Division of Pediatric Hematology and Oncology, Ibaraki Children’s Hospital, Mito, Ibaraki, Japan; Department of Hematology/Oncology, Saitama Children’s Medical Center, Saitama, Saitama,...
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Pleuropulmonary blastoma (PPB) is a rare pediatric malignancy whose pathogens are poorly understood. Recent reports suggest that germline mutations in the microRNA-processing enzyme DICER1 may contribute to PPB development. To investigate the genetic basis of this cancer, we performed whole-exome sequencing or targeted deep sequencing of multiple cases of PPB. We found biallelic DICER1 mutation...
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This paper is concerned with the problem of identifying names which occur frequently in an ordered list of names. Such names are called hot spots. Hot spots can be identiied easily by counting the occurrences of each name and then selecting those with large counts. However, this simple solution requires space proportional to the number of names that occur in the list. In this paper, we present ...
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ژورنال
عنوان ژورنال: Histopathology
سال: 2018
ISSN: 0309-0167
DOI: 10.1111/his.13630